In response to a question about how he arrived at his diagnosis Sotos had this to say after discounting Loeys-Dietzs syndrome:
So, I just worked on that sort of accumulation of facts for the book, and then one night a light bulb sort of went on. I was reading a different article entirely and it made me think of medullary thyroid carcinoma which is associated with marfanoid habidis [overgrowth of bones resulting in long limbs] in a syndrome known as MEN2B. And I thought, well, maybe I’ll just check out MEN2B in Lincoln and see if that’s a match.
And what is the evidence for MEN2B and the cancer which accompanies it?:
Visitors to the White House frequently spoke of how thin he looked. Then in his last three months his health turned for the worse. He was almost continuously ill in one way or another and my suspicion — and I won’t go so far as to say my diagnosis — but it is suspicious that he had three symptoms of pheochromocytoma during this time: headache, orthostatic syncope [he would faint when standing up] and cold, clammy hands and feet, which he complained to a friend about. In fact, this friend saw Lincoln put his feet so close to the fire that they steamed.
You can read more about Sotos’s speculations in his self-published book titled The Physical Lincoln. Turns out that shorter pieces were rejected in peer-reviewed journals for one reason or another. I wonder why?